Using an experimental approach to describing and understanding psychopathology, the course focuses on the aetiology and treatment of bipolar and related disorders, depressive  disorders and substance-related disorders. Since the clinical psychologist must be familiar with the modern clinical psychology landscape, Part I of this course provides a synopsis of key elements of experimental psychopathology research, its methods and its strategies. Part II addresses the developments that have occurred in both science and clinical practice in depressive and bipolar mood disorders, providing an up-to-date summary of these advancements. Part III addresses substance abuse with a broad and deep grounding in experimental methods. Finally, the complex relationship between substance use disorders and mood disorders (e.g., dual disorders) will be explored.