Molecular Genetic Analysis of Development (SBL.00119/ BL.0119 / 4582)
This
course is an introduction into some of the most popular animal model
systems used for the study of development. These include Xenopus, mice, Drosophila, C. elegans,
and Zebrafish. In doing so we will critically evaluate the value of
different technical approaches that are being used for the study of
development. Further emphasis will be on presenting key experiments and
results obtained with each system, and on presenting the most recent
research that is being performed in these systems. Topics may vary from
year to year but are likely to include transcriptional, translational
and post-translational regulation of gene expression. We will also
analyze the function of chromatin structure, signaling pathways and mRNA
localization during cellular differentiation. While
analyzing different pathways, we will focus on identifying molecules
that drive cell fate determination and patterning during development and
on their mode of action. Experimental approaches include classical
forward genetics, complementation, RNA interference, CRISPR-mediated
gene editing, transgenesis and more.
- Enseignant·e: Alessandro Puoti
- Enseignant·e: Beat Suter